Our client, a world leader in biotechnology and life sciences, is looking for an “Scientist II (Oligonucleotide Synthesis)” based in South San Francisco, CA.

Job Duration: Long Term Contract (Possibility Of Extension)
Rate: $51/hr on W2
Company Benefits: Medical, Dental, Vision, Paid Sick leave, 401K

Overview
This role focuses on oligonucleotide therapeutics discovery, supporting RNAi-based research through synthesis, characterization, and collaboration across therapeutic areas.

Key Responsibilities

Design and execute oligonucleotide synthesis and purification workflows.
Perform HPLC and mass spectrometer analysis for characterization and impurity profiling.
Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
Develop and scale up synthesis of lead oligonucleotide candidates for pre clinical studies.
Collaborate with cross-functional teams to integrate chemistry and biology data.
Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
Conduct literature reviews and contribute to experimental design and strategy.

Qualifications

BS/MS in Organic Chemistry or related field.
Hands-on experience with oligonucleotide synthesis, purification, and characterization.
Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.

If interested, please send us your updated resume at hr@dawarconsulting.com/lakshmi@dawarconsulting.com.

Competências necessárias

Oligonucleotide synthesisOligonucleotide purification workflows (HPLC-based)HPLC operation and method developmentMass spectrometry for characterization and impurity profilingAutomated oligonucleotide synthesizer operation and troubleshootingScale-up of oligonucleotide synthesis for preclinical studiesLaboratory equipment maintenance and troubleshooting (oligo synthesizers, HPLC systems)RNAi and nucleic acid therapeutics knowledgeNucleic acid modification chemistriesCross-functional collaboration and integration of chemistry and biology dataExperimental design and literature review for therapeutic discoveryOrganic chemistry principles

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